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Cell-matrix interactions in tooth development.

I Thesleff1, S Vainio, M Jalkanen

  • 1Department of Pedodontics and Orthodontics, University of Helsinki, Finland.

The International Journal of Developmental Biology
|March 1, 1989
PubMed
Summary
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Tooth development involves reciprocal epithelial-mesenchymal interactions. Cell-matrix interactions, particularly involving fibronectin and tenascin, regulate mesenchymal cell differentiation into odontoblasts.

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Extracellular Matrix Research

Background:

  • Tooth morphogenesis and cell differentiation are regulated by epithelial and mesenchymal tissue interactions.
  • Early interactions initiate oral epithelium budding and mesenchymal cell condensation.
  • During the bell stage, mesenchymal cells near the dental epithelium differentiate into odontoblasts.

Purpose of the Study:

  • To review descriptive and experimental studies on tooth development.
  • To elucidate the role of cell-surface and extracellular matrix interactions in odontoblast differentiation and mesenchymal cell condensation.

Main Methods:

  • Descriptive and experimental studies.
  • Transfilter culture studies separating dental epithelium and mesenchyme.

Related Experiment Videos

  • Immunohistochemical localization of matrix molecules.

    • Main Results:

    • Cell-surface and extracellular matrix interactions regulate odontoblast differentiation and mesenchymal cell condensation.
    • Transfilter studies suggest epithelial basement membrane matrix interactions trigger odontoblast differentiation.
    • Fibronectin and tenascin accumulate in the dental basement membrane during odontoblast differentiation.

    Conclusions:

    • Mesenchymal cell condensation and odontoblast differentiation are regulated by cell-matrix interactions.
    • Fibronectin and tenascin are implicated in the cell-matrix interactions driving odontoblast polarization and differentiation.