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[The association of duration of hypertension and changes in cognitive function in hypertension patients]

Tuo Li, Junwu Xiang, Jie Bai

  • 1Department of Neurology, Changzheng Hospital, Shanghai 200003, China.

Zhonghua Nei Ke Za Zhi
|May 27, 2014
PubMed

Insights

Longer hypertension duration is linked to worse cognitive function. Patients with hypertension over 20 years showed significantly more cognitive dysfunction, highlighting hypertension as a risk factor for cognitive decline.

Area of Science:

  • Neurology
  • Cardiology
  • Gerontology

Background:

  • Hypertension is a prevalent condition affecting cardiovascular health.
  • Cognitive function can be impacted by various systemic diseases.
  • The long-term effects of hypertension on cognition require further investigation.

Purpose of the Study:

  • To examine the association between the duration of hypertension and cognitive function in adults.
  • To compare cognitive performance across different durations of hypertension and a normotensive control group.

Main Methods:

  • A cohort study involving 224 normotensive subjects and 1,296 hypertensive patients categorized by hypertension duration (≤5, 6-10, 11-20, >20 years).
  • Cognitive function assessed using the Mini-Mental State Examination (MMSE) and Clock-Drawing Test (CDT).
  • Statistical analysis performed using SPSS 18.0 to compare cognitive impairment incidences and assess relationships.

Main Results:

  • Hypertensive patients exhibited poorer performance in MMSE, CDT, memory, and non-memory cognitive functions compared to normotensive individuals.
  • The incidence of cognitive impairment increased with hypertension duration, rising from 3.6% in normotensive to 33.5% in those with hypertension >20 years.
  • Cognitive function was significantly worse in the hypertension group with >20 years duration compared to the normotensive group.

Conclusions:

  • Hypertension is identified as a significant risk factor for cognitive dysfunction.
  • Both the incidence and severity of cognitive dysfunction are positively correlated with the duration of hypertension.
  • Individuals with hypertension exceeding 20 years demonstrate markedly more pronounced cognitive dysfunction.
Abstract

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