Related Experiment Video
Updated: Apr 29, 2026

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
Published on: March 4, 2014
[Evaluation of serum creatinine level in amyotrophic lateral sclerosis patients]
Yuting Ren1, Wenjia Zhu1, Fang Cui1
1Department of Neurology, Chinese PLA General Hospital, Beijing 100853, China.
Objective:
To investigate the serum creatinine (SCr) level in patients with sporadic amyotrophic lateral sclerosis (sALS) and to explore the relationship between the SCr level and the clinical characteristics.
Methods:
A total of 80 patients with sALS, 80 patients with multiple system atrophy (MSA) and 80 patients with tension-type headache (TTH) were enrolled in the study. The SCr levels were compared among the three groups. The association between the SCr level and the revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R), the forced vital capacity (FVC) percentage of predicted (FVC%pred), the site of symptom onset, the duration of disease and the rate of disease progression was evaluated in the sALS group.
Results:
The SCr level was significantly decreased in the sALS group than the other two groups [(60.86 ± 16.80) µmol/L vs (70.05 ± 12.79) µmol/L and (66.97 ± 14.14) µmol/L, P < 0.01].In the sALS group, the SCr level was positively correlated with the ALSFRS-R (r = 0.315, P = 0.005), while no correlation was found between the SCr level and the FVC%pred, the site of symptom onset, the duration of disease and the rate of disease progression (all P > 0.05).
Conclusion:
The SCr level is an important biochemical index in the patients with sALS and might play an important role in monitoring the disease progression.
Related Concept Videos
Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
Serum Studies: Renal Function Tests
Factors Affecting Renal Clearance: Renal Impairment
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate

