Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Human Genetics01:28

Human Genetics

2.0K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
2.0K
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

2.5K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
2.5K
Epigenetic Regulation01:46

Epigenetic Regulation

28.7K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
28.7K
Epigenetic Regulation01:37

Epigenetic Regulation

3.4K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.4K
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

119
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
119
Introduction to Biological Bases of Psychology01:30

Introduction to Biological Bases of Psychology

5.7K
Biopsychology serves as a vital bridge connecting the intricate domains of biology and psychology, shedding light on how biological systems influence psychological phenomena. This field scrutinizes the biological substrates of behavior and mental processes, emphasizing the nervous system along with the roles of neurotransmitters, hormones, and genetics. It also incorporates evolutionary perspectives to explain the adaptive nature of mental functions.
The nervous system, the cornerstone of...
5.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: ​​Enhancing the sensitivity of non-invasive cervical cancer detection using CpG methylation haplotype profiling.

Scientific reports·2026
Same author

Cross-Generational Embedding of Adverse Childhood Experiences.

Biological psychiatry·2025
Same author

DNA Methylation Mediates the Association Between Prenatal Maternal Stress and the Broad Autism Phenotype in Human Adolescents: Project Ice Storm.

International journal of molecular sciences·2025
Same author

Enhancing the sensitivity of non-invasive cervical cancer detection using CpG methylation haplotype profiling.

Scientific reports·2025
Same author

The epiMelanoma test enables plasma-based detection of melanoma and prediction of immunotherapy response.

Scientific reports·2025
Same author

Correction for: EpiAge: a next-generation sequencing-based <i>ELOVL2</i> epigenetic clock for biological age assessment in saliva and blood across health and disease.

Aging·2025

Related Experiment Video

Updated: Apr 29, 2026

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models
13:47

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models

Published on: March 29, 2019

9.6K

Epigenetics, a key for unlocking complex CNS disorders? Therapeutic implications.

Moshe Szyf1

  • 1Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada H3G1Y5.

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
|May 27, 2014
PubMed
Summary
This summary is machine-generated.

Epigenetic mechanisms, not just DNA sequence changes, significantly impact gene function and are implicated in brain diseases. These epigenetic factors offer potential biomarkers and reversible therapeutic targets for mental health disorders.

Keywords:
Alzheimer diseaseDNA methylationEarly life adversityEpigenetic therapyEpigeneticsEpilepsyHistone deacetylase (HDAC) inhibitorsS-adenosylmethionine (SAM)SchizophreniaValproic acid

More Related Videos

Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders
05:00

Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders

Published on: November 11, 2022

2.9K
A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior
06:59

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior

Published on: May 21, 2020

3.6K

Related Experiment Videos

Last Updated: Apr 29, 2026

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models
13:47

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models

Published on: March 29, 2019

9.6K
Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders
05:00

Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders

Published on: November 11, 2022

2.9K
A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior
06:59

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior

Published on: May 21, 2020

3.6K

Area of Science:

  • Neuroscience
  • Genetics
  • Molecular Biology

Background:

  • Aberrant gene function contributes to diverse human diseases, including behavioral, cognitive, and neurodegenerative disorders.
  • While DNA sequence alterations are studied, they explain only a small fraction of disease cases, suggesting other regulatory mechanisms are involved.
  • Gene-environment interactions in the brain are increasingly recognized as crucial factors influencing phenotype and disease.

Purpose of the Study:

  • To explore the role of epigenetic mechanisms in regulating gene function and their connection to brain diseases.
  • To highlight the potential of epigenetic markers as biomarkers for neurological and behavioral conditions.
  • To discuss the therapeutic implications of potentially reversible epigenetic processes.

Main Methods:

  • Review of existing literature on gene function, DNA sequence alterations, and epigenetic mechanisms (e.g., chromatin structure, DNA methylation).
  • Analysis of evidence supporting gene-environment interactions in the brain.
  • Exploration of the role of epigenetic modifications in cellular differentiation and gene expression regulation.

Main Results:

  • Epigenetic mechanisms, including chromatin modification and DNA methylation, play a critical role in programming gene function and identity.
  • Epigenetic differences are proposed to mediate gene function changes in response to environmental contexts, leading to altered gene networks and brain disease.
  • Epigenetic markers show promise as significant biomarkers for brain and behavioral diseases.

Conclusions:

  • Epigenetic processes are fundamental to gene regulation and are implicated in the etiology of various brain disorders.
  • Epigenetic modifications offer a new perspective beyond DNA sequence variations in understanding disease mechanisms.
  • The reversible nature of epigenetic processes suggests potential for novel epigenetic therapeutics in psychotherapy and brain disease treatment.