Related Experiment Video
Updated: Apr 29, 2026

A Structured Approach to Extubation in Mechanically Ventilated Rats
Published on: July 18, 2025
[Successful weaning and extubation in the premature newborn using neurally adjusted ventilatory assist]
F García-Muñoz Rodrigo1, S Rivero Rodríguez1, A Florido Rodríguez1
1Servicio de Neonatología, Complejo Hospitalario Universitario Insular Materno-Infantil de Canarias, Las Palmas de Gran Canaria, España.
Abstract:
Invasive and non-invasive ventilation of the preterm newborn may be associated with local and systemic complications due to mechanical trauma to lung tissues and their inflammatory response. A key objective of any type of mechanical ventilation, therefore, is to reduce its duration and the side effects related to it. Neurally Adjusted Ventilatory Assist (NAVA) may improve synchronization between patient and ventilator and optimize the gas volume delivered to the lungs, according to the patient needs, eventually reducing volu- and biotrauma. Two preterm babies with severe respiratory distress syndrome are presented, who were successfully weaned and extubated with the help of this ventilatory system. Further studies are needed to assess whether short-term benefits are reflected in better outcomes in the long run.
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