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Updated: Apr 29, 2026
10:29
Simulating Pancreatic Neuroplasticity: In Vitro Dual-neuron Plasticity Assay
Published on: April 14, 2014
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Nonfunctional pancreatic neuroendocrine tumors
Jennifer H Kuo1, James A Lee2, John A Chabot1
1Division of GI/Endocrine Surgery, Columbia University, 161 Fort Washington Avenue, 8th Floor, New York, NY 10032, USA.
The Surgical Clinics of North America
|May 27, 2014
Summary
Pancreatic neuroendocrine tumors (PNETs) are rare and increasing. Most PNETs are nonfunctional, presenting with mass effect or metastasis, and this review covers their diagnosis, surgery, and treatments.
Area of Science:
- Oncology
- Endocrinology
- Gastroenterology
Background:
- Pancreatic neuroendocrine tumors (PNETs) are rare neoplasms with increasing incidence.
- Diagnosis is often incidental via cross-sectional imaging (pancreatic incidentalomas).
- Most PNETs are nonfunctional, causing symptoms via mass effect or metastasis.
Purpose of the Study:
- To review the diagnostic algorithm for nonfunctional PNETs.
- To discuss surgical management strategies for nonfunctional PNETs.
- To outline available systemic therapies for nonfunctional PNETs.
Main Methods:
- Review of diagnostic approaches.
- Analysis of surgical interventions.
- Summary of systemic treatment options.
Main Results:
- Nonfunctional PNETs present heterogeneously, often incidentally.
- Diagnosis relies on imaging and biochemical evaluation.
- Management involves a multidisciplinary approach including surgery and systemic therapy.
Conclusions:
- Nonfunctional PNETs require a tailored diagnostic and management strategy.
- Surgical resection is a key treatment modality when feasible.
- Systemic therapies offer options for advanced or metastatic disease.
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