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Updated: Feb 9, 2026

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches
Published on: April 20, 2021
Manipulating the epigenome in germinal center lymphomas: is it getting easier and ezier?
Jennifer E Amengual1, Owen A O'Connor2
1Authors' Affiliation: Center for Lymphoid Malignancies, Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.
Abstract:
Mutations affecting key epigenetic modifiers tend to cluster in malignancies in which cells of origin lie in the germinal center (GC). EZH2, as transcriptional repressor, is mutated in high frequency in Chinese and Western patients with follicular lymphoma and may represent a rational target for GC-derived lymphomas. .
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