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Updated: Apr 29, 2026

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
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Less understood issues: p21(Cip1) in mitosis and its therapeutic potential

N-N Kreis1, F Louwen1, J Yuan1

  • 1Department of Gynecology and Obstetrics, J.W. Goethe-University, Frankfurt, Germany.

Oncogene
|May 27, 2014
PubMed
Summary

The cell cycle regulator p21 (also known as Cip1) is crucial for mitosis. Loss of p21 causes mitotic defects and genomic instability, while its stabilization in tumor cells suggests a role in cancer therapy.

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