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Comparative in vitro study of RGH-2981, a new peripheral blood flow enhancer on animal and pathological human
Z Szombathelyi1, E Kárpáti, A Till
1Chemical Works of G. Richter, Pharmacological Research Centre, Budapest, Hungary.
Polish Journal of Pharmacology and Pharmacy
|November 1, 1989
Abstract:
The aim of the present investigation was to compare the activity of RGH-2981 and two reference compounds, verapamil and LY 53857 on isolated, normal animal and pathological human arteries. The majority of the latter displayed vasoconstriction against 5-HT, or KCl, what evidences that despite serious vascular damage they did not develop a total functional failure. RGH-2981 showed a moderate serotonin and Ca++ antagonistic activity in both normal rabbit and pathological human arteries.