Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structure of Cardiac Muscles01:13

Structure of Cardiac Muscles

16.6K
Cardiac muscle, or myocardium, is a specialized type of muscle found exclusively in the heart. Its unique structural and functional characteristics enable the heart to perform its vital role of pumping blood throughout the body continuously and rhythmically. The cardiac muscle cells, or cardiomyocytes, possess an endomysium and perimysium but do not have an epimysium.
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
16.6K
Specialized Characteristics of Cardiac Muscles01:27

Specialized Characteristics of Cardiac Muscles

6.7K
The primary role of cardiac muscles is to propel blood throughout the cardiovascular system. The cardiac muscle cells, or cardiomyocytes, exhibit specialized characteristics that allow them to perform this function.
Cardiac muscle cells are smaller than skeletal muscles, averaging 10–20 mm in diameter and 50–100 mm in length. However, they have large energy demands for continuous contraction and relaxation. This energy is almost exclusively derived from aerobic metabolism of energy...
6.7K
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

2.2K
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
2.2K
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

1.2K
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
1.2K
Heart Failure Drugs: Inotropic Agents01:26

Heart Failure Drugs: Inotropic Agents

1.9K
Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
1.9K
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

645
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
645

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of a shorter algorithm in an automated analysis of sublingual microcirculation.

Clinical hemorheology and microcirculation·2020
Same author

Comprehensive Analysis of Macrocirculation and Microcirculation in Microgravity During Parabolic Flights.

Frontiers in physiology·2020
Same author

Aortic valve calcification is subject to aortic stenosis severity and the underlying flow pattern.

Heart and vessels·2020
Same author

Risk modeling in transcatheter aortic valve replacement remains unsolved: an external validation study in 2946 German patients.

Clinical research in cardiology : official journal of the German Cardiac Society·2020
Same author

One-Year Course of Periprocedural Anticoagulation in Atrial Fibrillation Ablation: Results of a German Nationwide Survey.

Cardiology·2020
Same author

Frailty Assessment in Patients Undergoing Aortic Valve Replacement: Be Quick and Be Sure.

JACC. Cardiovascular interventions·2020

Related Experiment Video

Updated: Apr 29, 2026

Intra-cardiac Side-Firing Light Catheter for Monitoring Cellular Metabolism using Transmural Absorbance Spectroscopy of Perfused Mammalian Hearts
08:51

Intra-cardiac Side-Firing Light Catheter for Monitoring Cellular Metabolism using Transmural Absorbance Spectroscopy of Perfused Mammalian Hearts

Published on: May 12, 2019

8.8K

Myoglobin functions in the heart.

Ulrike B Hendgen-Cotta1, Malte Kelm1, Tienush Rassaf1

  • 1University Hospital Düsseldorf, Medical Faculty, Division of Cardiology, Pulmonology, and Vascular Medicine, D-40225 Düsseldorf, Germany.

Free Radical Biology & Medicine
|May 27, 2014
PubMed
Summary
This summary is machine-generated.

Myoglobin (Mb) in the heart acts as an oxygen store and sensor. Its oxygenation state determines its role in nitric oxide (NO) homeostasis, protecting the heart during hypoxia and ischemia.

Keywords:
Free radicalsMyoglobinNitric oxideNitriteOxygen

More Related Videos

Analysis of Cardiac Contractile Dysfunction and Ca2+ Transients in Rodent Myocytes
07:32

Analysis of Cardiac Contractile Dysfunction and Ca2+ Transients in Rodent Myocytes

Published on: May 25, 2022

1.6K
A Simple and Effective Method to Consistently Isolate Mouse Cardiomyocytes
06:25

A Simple and Effective Method to Consistently Isolate Mouse Cardiomyocytes

Published on: November 11, 2022

3.6K

Related Experiment Videos

Last Updated: Apr 29, 2026

Intra-cardiac Side-Firing Light Catheter for Monitoring Cellular Metabolism using Transmural Absorbance Spectroscopy of Perfused Mammalian Hearts
08:51

Intra-cardiac Side-Firing Light Catheter for Monitoring Cellular Metabolism using Transmural Absorbance Spectroscopy of Perfused Mammalian Hearts

Published on: May 12, 2019

8.8K
Analysis of Cardiac Contractile Dysfunction and Ca2+ Transients in Rodent Myocytes
07:32

Analysis of Cardiac Contractile Dysfunction and Ca2+ Transients in Rodent Myocytes

Published on: May 25, 2022

1.6K
A Simple and Effective Method to Consistently Isolate Mouse Cardiomyocytes
06:25

A Simple and Effective Method to Consistently Isolate Mouse Cardiomyocytes

Published on: November 11, 2022

3.6K

Area of Science:

  • Cardiovascular Physiology
  • Biochemistry
  • Cellular Respiration

Background:

  • Myoglobin (Mb) is crucial for cardiac oxygen (O2) homeostasis, with myocardial partial pressure of oxygen (pO2) varying transmurally.
  • Mb functions as an O2 storage depot, particularly during systole, and influences myocardial nitric oxide (NO) levels.

Purpose of the Study:

  • To review the established and emerging roles of myoglobin in cardiac physiology and pathology.
  • To elucidate myoglobin's function as an O2 sensor and its impact on NO homeostasis.

Main Methods:

  • Literature review summarizing existing research on myoglobin's cardiac functions.
  • Discussion of myoglobin's dual role in NO scavenging (oxygenated) and production (deoxygenated) under varying oxygen conditions.

Main Results:

  • Oxygenated myoglobin scavenges NO, protecting the heart from excessive NO toxicity.
  • Deoxygenated myoglobin acts as an NO producer under hypoxia, offering protection against ischemia/reperfusion injury.

Conclusions:

  • Myoglobin is a critical O2 sensor in the heart, modulating NO levels based on oxygen availability.
  • Myoglobin's dynamic role in NO metabolism is key to cardiac protection during physiological stress and pathological conditions like hypoxia and ischemia.