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Updated: Apr 29, 2026

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
Published on: March 24, 2023
Automatic individualized contrast medium dosage during hepatic computed tomography by using computed tomography dose
Anders Svensson1, Jonas Björk, Kerstin Cederlund
1Department of Clinical Science, Division of Medical Imaging and Technology, Intervention and Technology at Karolinska Institutet, Stockholm, Sweden, anders.svensson@ki.se.
Volume-corrected computed tomography dose index (CTDIvol) correlates with liver contrast media enhancement, similar to body weight. CTDIvol may enable automated, individualized contrast dosing in CT scans.
Area of Science:
- Radiology
- Medical Imaging
- Computed Tomography
Background:
- Contrast media (CM) enhancement in liver imaging is crucial for diagnosis.
- Optimizing CM dosage based on patient size is essential for effective imaging and safety.
Purpose of the Study:
- To compare hepatic parenchymal contrast media enhancement during multi-detector row computed tomography (MDCT).
- To evaluate the correlation between CM enhancement and dose index (CTDIvol) and body weight (BW).
Main Methods:
- One hundred patients undergoing MDCT received intravenous iodixanol or iomeprol followed by saline flush.
- Liver parenchymal enhancement was measured as the difference in Hounsfield Units (HU) between contrast-enhanced and native phases.
- CTDIvol and body weight (BW) were recorded for correlation analysis.
Main Results:
- Liver parenchymal enhancement showed a negative correlation with both CTDIvol (r = -0.60) and BW (r = -0.64).
- The correlation strength between CTDIvol and BW was not statistically significant.
Conclusions:
- CTDIvol is a significant factor related to liver CM enhancement in the parenchymal phase.
- CTDIvol offers comparable information to BW for adjusting CM dosage.
- CTDIvol can potentially be used for automated, individualized CM dosing in CT examinations.
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