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Risk of coronary artery disease in patients with systemic sclerosis: a systematic review and meta-analysis

Patompong Ungprasert1, Prangthip Charoenpong, Praveen Ratanasrimetha

  • 1Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, P.Ungprasert@gmail.com.

Clinical Rheumatology
|May 27, 2014
PubMed

Insights

Patients with systemic sclerosis (SSc) face a significantly higher risk of developing coronary artery disease (CAD). This meta-analysis confirms a 1.82 times increased risk, highlighting a critical link between SSc and heart health.

Area of Science:

  • Cardiology
  • Rheumatology
  • Epidemiology

Background:

  • Chronic inflammatory disorders like rheumatoid arthritis and lupus increase coronary artery disease (CAD) risk.
  • The association between systemic sclerosis (SSc) and CAD risk remains unclear.

Purpose of the Study:

  • To systematically review and meta-analyze observational studies assessing CAD risk in patients with SSc.
  • To quantify the pooled risk ratio of CAD in individuals diagnosed with SSc compared to non-SSc individuals.

Main Methods:

  • Systematic review and meta-analysis of observational studies.
  • Inclusion criteria: studies reporting risk estimates (OR, RR, HR, SIR) for CAD in SSc patients.
  • Data synthesis using a random-effects, generic inverse variance method.

Main Results:

  • Four studies were included in the analysis.
  • The pooled risk ratio for CAD in patients with SSc was 1.82 (95% CI, 1.40 to 2.36).
  • Moderate statistical heterogeneity was observed (I² = 73%).

Conclusions:

  • Systemic sclerosis is associated with a statistically significant increased risk of coronary artery disease.
  • Findings underscore the importance of cardiovascular risk assessment in SSc patients.

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