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Updated: Apr 29, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

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Cerebral small artery diseases may be associated with aortic arch calcification in stroke patients

Yuji Ueno1, Ayami Okuzumi, Masao Watanabe

  • 1Department of Neurology, Juntendo University Urayasu Hospital.

Journal of Atherosclerosis and Thrombosis
|May 27, 2014
PubMed

Insights

Aortic arch calcification (AoAC) on chest X-rays is linked to small artery occlusion (SAO) stroke. Key factors include age, hypertension, diabetes, and white matter lesions.

Area of Science:

  • Cardiology
  • Neurology
  • Radiology

Background:

  • Aortic arch calcification (AoAC) on chest X-rays indicates systemic atherosclerosis and is linked to ischemic cardiovascular diseases.
  • The specific association between AoAC and ischemic stroke subtypes requires further clarification.

Purpose of the Study:

  • To investigate the relationship between the extent of AoAC on chest X-rays and different subtypes of acute ischemic stroke.
  • To identify clinical, biochemical, and imaging factors associated with AoAC in stroke patients.

Main Methods:

  • Prospective study of 175 acute ischemic stroke patients undergoing chest X-ray, blood tests, and brain MRI.
  • AoAC extent was graded (0-3) on chest X-rays.
  • Clinical data, biochemical findings, white matter lesions, and AoAC extent were analyzed across stroke subtypes.

Main Results:

  • AoAC extent was independently correlated with small artery occlusion (SAO) stroke.
  • Significant associations were found between AoAC and age, hypertension, diabetes mellitus, white matter lesions, and SAO.
  • Age (OR: 1.14), hypertension (OR: 3.44), white matter lesions (OR: 1.54), and SAO (OR: 1.38) were significant factors.

Conclusions:

  • Age, hypertension, and cerebral small artery disease are strongly associated with AoAC in acute ischemic stroke patients.
  • Diabetes mellitus may also be closely associated with AoAC.
Abstract

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