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Activating transcription factor 3 promotes colon cancer metastasis

Zhi-Yong Wu1, Zheng-Mao Wei, Sheng-Jie Sun

  • 1Department of Oncology, Chinese PLA General Hospital, Beijing, China.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
|May 27, 2014
PubMed

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Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
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No description available
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Transcription activators are proteins that promote the transcription of genes from DNA to RNA. In most cases, these proteins contain two separate domains ‒ a domain that binds to DNA and a domain for activating transcription; however, in some cases, a single domain is responsible for both binding and activation of transcription, as seen in the glucocorticoid receptor and MyoD.
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The organization of prokaryotic genes in their genome is notably different from that of eukaryotes. Prokaryotic genes are organized, such that the genes for proteins involved in the same biochemical process or function are located together in groups. This group of genes, along with their regulatory elements, are collectively known as an operon. The functional genes in an operon are transcribed together to give a single strand of mRNA known as polycistronic mRNA.
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