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Related Experiment Videos

Nephrocalcinosis due to vitamin D intoxication.

N Beşbaş, A Oner, O Akhan

    The Turkish Journal of Pediatrics
    |July 1, 1989
    PubMed
    Summary

    Vitamin D intoxication in infants occurred with high daily doses (30,000-60,000 IU/day) for 1-3 months. This led to severe hypercalcemia, hyperphosphatemia, and nephrocalcinosis, requiring careful monitoring and prevention strategies.

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    Area of Science:

    • Pediatrics
    • Endocrinology
    • Toxicology

    Background:

    • Vitamin D is essential for bone health, but excessive intake can lead to toxicity.
    • Infant susceptibility to vitamin D toxicity requires careful dosage considerations.

    Observation:

    • Two infants (3 and 4 months old) received high-dose vitamin D (30,000-60,000 IU/day) for 1-3 months.
    • Patients presented with severe hypercalcemia (17.6-19.5 mg/dl) and hyperphosphatemia (2.6-3.2 mg/dl).
    • Renal ultrasonography revealed medullary nephrocalcinosis in both infants.

    Findings:

    • High-dose vitamin D administration in infants can cause severe intoxication.
    • Clinical manifestations include significant hypercalcemia and hyperphosphatemia.
    • Nephrocalcinosis is a critical ultrasonographic finding in vitamin D toxicity.

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    Implications:

    • Emphasizes the need for strict adherence to recommended vitamin D dosages in infants.
    • Highlights the importance of monitoring calcium and phosphorus levels in infants receiving vitamin D supplementation.
    • Suggests that early detection and intervention are crucial for managing vitamin D intoxication and preventing renal damage.