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Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
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Breast pathology review: does it make a difference?

Anya M Romanoff1, Almog Cohen, Hank Schmidt

  • 1Department of Surgery, Dubin Breast Center, Mount Sinai Medical Center, New York, NY, USA, anyamromanoff@gmail.com.

Annals of Surgical Oncology
|May 27, 2014
PubMed
Summary
This summary is machine-generated.

Mandatory breast pathology review significantly altered diagnoses and surgical plans in 17% and 10% of cases, respectively. This review is crucial for accurate breast disease management, especially for benign diagnoses.

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Area of Science:

  • Pathology
  • Oncology
  • Surgical Management

Background:

  • Breast pathology diagnoses can have discrepancies, even among experts.
  • Accurate diagnosis is critical for appropriate surgical management of breast disease.

Purpose of the Study:

  • To determine if mandatory pathology review impacts breast disease diagnosis and surgical management.
  • To evaluate the rate of diagnostic and management changes following expert pathology review.

Main Methods:

  • Expert breast pathologists reviewed 430 biopsy specimens from 306 patients over two years.
  • Compared initial diagnoses and surgical management plans with second opinion reports.
  • Analyzed changes based on initial diagnosis, specimen type, and originating institution.

Main Results:

  • Seventy-two cases (17%) had diagnostic changes, and 41 (10%) had surgical management changes.
  • Diagnostic changes were more frequent for initially benign diagnoses (31%) compared to malignant (7%).
  • Twelve benign diagnoses were reclassified as malignant; 4 malignant diagnoses were reclassified as benign.

Conclusions:

  • Breast pathology review is recommended based on clinical scenarios, irrespective of the initial diagnosis or institution.
  • Expert review can identify significant diagnostic and management discrepancies.
  • Consideration of pathology review can improve patient care in breast disease.