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Updated: Apr 29, 2026
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Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections
Published on: February 2, 2024
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Fungal osteomyelitis and septic arthritis
Jason T Bariteau1, Gregory R Waryasz1, Matthew McDonnell1
1From the Division of Orthopaedic Trauma, Department of Orthopaedics, Warren Alpert Medical School of Brown University, Providence, RI.
Summary
Fungal osteomyelitis and septic arthritis are rare, challenging infections, particularly in immunocompromised patients. Limited evidence exists, but guidelines aid management of common and endemic fungal pathogens.
Area of Science:
- Infectious Diseases
- Rheumatology
- Orthopedics
Background:
- Fungal osteomyelitis and septic arthritis are rare and challenging infections.
- Management is difficult in immunocompromised patients due to limited research and poor historical outcomes.
- Common pathogens include Candida and Aspergillus; endemic fungi like Histoplasma also cause infections.
Purpose of the Study:
- To review the pathophysiology, diagnosis, and treatment of fungal bone and joint infections.
- To highlight challenges in managing these rare conditions, especially in specific patient populations.
- To discuss available guidelines for managing various fungal pathogens.
Main Methods:
- Literature review of fungal osteomyelitis and septic arthritis.
- Analysis of common and endemic fungal pathogens.
- Discussion of infection routes (direct inoculation, contiguous spread, hematogenous seeding).
Main Results:
- Fungal bone and joint infections are difficult to diagnose and eradicate.
- Total joint arthroplasty increases diagnostic and therapeutic challenges.
- While consensus is lacking, guidelines exist for managing many fungal pathogens.
Conclusions:
- Effective management of fungal osteomyelitis and septic arthritis requires understanding specific pathogens and patient factors.
- Despite challenges, available guidelines offer a framework for treatment.
- Further research is needed to improve evidence-based strategies for these rare infections.
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