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Related Experiment Video

Updated: Apr 29, 2026

Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes
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Using SCOPE to Identify Potential Regulatory Motifs in Coregulated Genes

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Motif enrichment tool.

Charles Blatti1, Saurabh Sinha2

  • 1Department of Computer Science, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA blatti@illinois.edu.

Nucleic Acids Research
|May 27, 2014
PubMed
Summary
This summary is machine-generated.

The Motif Enrichment Tool (MET) identifies key transcriptional regulators for gene sets by analyzing DNA-binding motifs. This free online tool enhances regulatory target discovery using high-throughput data and provides real-time results linked to a genome browser.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Molecular Biology

Background:

  • Identifying transcriptional regulators is crucial for understanding gene regulation.
  • Existing methods may lack precision or accessibility for analyzing large gene sets.

Purpose of the Study:

  • To present the Motif Enrichment Tool (MET), an online platform for identifying major transcriptional regulators.
  • To enable users to find statistically overrepresented transcription factor DNA-binding specificities (motifs) within their gene sets.

Main Methods:

  • MET analyzes regulatory regions of user-provided gene sets.
  • It performs motif enrichment analysis across various metazoan species.
  • Integrates high-throughput data (ChIP-seq, DNase-seq) from ENCODE and ModENCODE for precise target identification.

Main Results:

  • MET provides statistically overrepresented transcription factor motifs in real time.
  • Identifies regulatory targets of transcription factors with enhanced precision.
  • Results are linked to a genome browser for immediate follow-up analysis.

Conclusions:

  • MET offers a free, accessible, and efficient online tool for motif enrichment analysis.
  • It facilitates the discovery of transcriptional regulators and their targets.
  • The tool supports research across multiple species, including human and mouse.