Jove
Visualize
Contact Us

Related Experiment Videos

1-Methyl-3-phenyl-thio-urea.

Hou-Xiang Su1

  • 1Lvliang University, Lvliang, Shanxi 033001, People's Republic of China.

Acta Crystallographica. Section E, Structure Reports Online
|May 27, 2014
PubMed
Summary

This study details the synthesis and crystal structure of a novel thio-urea compound. Molecular conformation and intermolecular hydrogen bonding in the crystal lattice were elucidated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Crystal structure of 1-(piperidin-1-yl)butane-1,3-dione.

Acta crystallographica. Section E, Structure reports online·2015
Same journal

Crystal structure of methyl 1-methyl-3,5-diphenyl-7-tosyl-3,6,7,11b-tetra-hydro-pyrazolo-[4',3':5,6]pyrano[3,4-c]quinoline-5a(5H)-carboxyl-ate.

Acta crystallographica. Section E, Structure reports online·2015
Same journal

Crystal structure of 4-amino-1-(4-methyl-benz-yl)pyridinium bromide.

Acta crystallographica. Section E, Structure reports online·2015
Same journal

Crystal structure of (Z)-3-benz-yloxy-6-[(2-hy-droxy-anilino)methyl-idene]cyclo-hexa-2,4-dien-1-one.

Acta crystallographica. Section E, Structure reports online·2015
Same journal

Crystal structure of bis-(1-benzyl-1H-1,2,4-triazole) perchloric acid monosolvate.

Acta crystallographica. Section E, Structure reports online·2015
Same journal

Crystal structure of 2-(di-phenyl-phos-phanyl)phenyl 4-(hy-droxy-meth-yl)benzoate.

Acta crystallographica. Section E, Structure reports online·2015
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Organic Chemistry
  • Crystallography
  • Chemical Synthesis

Background:

  • Thio-urea derivatives are important in medicinal chemistry and materials science.
  • Understanding molecular conformation and crystal packing is crucial for predicting material properties.

Purpose of the Study:

  • To synthesize a novel thio-urea compound.
  • To determine the molecular conformation and crystal structure of the synthesized compound.
  • To investigate intermolecular interactions within the crystal lattice.

Main Methods:

  • Chemical synthesis involving methyl-amine, potassium hydroxide (KOH), and phenyl-iso-thio-cyanate in ethanol.
  • Single-crystal X-ray diffraction analysis to determine the crystal structure.
  • Analysis of bond angles, dihedral angles, and hydrogen bonding patterns.

Main Results:

  • The compound C8H10N2S was successfully synthesized.
  • The molecule adopts a syn-Me and anti-Ph conformation relative to the C=S double bond.
  • Crystal structure analysis revealed centrosymmetrical dimers formed by N(Ph)-H⋯S hydrogen bonds, further organized into layers via N(Me)-H⋯S hydrogen bonds.

Conclusions:

  • The synthesis and structural characterization of the novel thio-urea compound were achieved.
  • The study provides insights into the conformational preferences and supramolecular assembly of thio-urea derivatives.
  • The identified hydrogen bonding network explains the observed crystal packing.

Related Experiment Videos