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Modulatory interactions between the default mode network and task positive networks in resting-state.

Xin Di1, Bharat B Biswal1

  • 1Department of Biomedical Engineering, New Jersey Institute of Technology , Newark, NJ , USA.

Peerj
|May 27, 2014
PubMed
Summary

The default mode network (DMN) and task-positive networks interact dynamically. The salience network, basal ganglia, and thalamus critically modulate these complex brain communications during rest.

Keywords:
Basal gangliaDynamic connectivityModulatory interactionPhysiophysiological interactionSalience networkThalamus

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Brain Imaging

Background:

  • The default mode network (DMN) and task-positive networks exhibit inverse connectivity at rest.
  • Understanding the modulation of these networks by other brain regions is crucial for comprehending brain function.

Purpose of the Study:

  • To investigate how other brain regions modulate connectivity between the DMN and task-positive networks.
  • To identify specific brain structures involved in these modulatory interactions.

Main Methods:

  • Resting-state functional magnetic resonance imaging (fMRI) data.
  • Physiological interaction (PPI) analysis to examine network modulation.
  • Spatial independent component analysis (ICA) to identify brain networks.

Main Results:

  • Reciprocal positive modulatory interactions were found between the DMN, salience network, and executive networks.
  • The salience network appears to play a key role in modulating DMN-executive network interactions.
  • Basal ganglia and thalamus showed complex positive and negative modulatory interactions with DMN and task-positive networks.

Conclusions:

  • Complex modulatory interactions exist between the DMN and task-positive networks at rest.
  • The salience network, basal ganglia, and thalamus are critical modulators of brain network communication.