Related Experiment Video
Updated: Apr 29, 2026
02:28
Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
Published on: March 1, 2024
1.1K
Metabolic syndrome in patients with psoriasis: A comparative study
Sristi Lakshmi1, Amiya Kumar Nath1, Carounanidy Udayashankar1
1Department of Dermatology, Indira Gandhi Medical College and Research Institute, Puducherry, India.
Indian Dermatology Online Journal
|May 27, 2014
Summary
Psoriasis patients do not show a strong link with metabolic syndrome (MS) in South India. Higher age and female gender were risk factors for MS in psoriasis patients, independent of disease severity.
Area of Science:
- Dermatology
- Cardiology
- Endocrinology
Background:
- Psoriasis is associated with an increased risk of metabolic syndrome (MS).
- Proinflammatory cytokines in psoriatic plaques contribute to MS features like hypertension, dyslipidemia, and insulin resistance.
Purpose of the Study:
- Determine the frequency of MS in psoriasis patients.
- Identify risk factors for MS in individuals with psoriasis.
Main Methods:
- A comparative hospital-based study included 40 adult psoriasis patients and 40 age- and sex-matched controls.
- All participants underwent evaluation for components of metabolic syndrome.
Main Results:
- Metabolic syndrome (MS) was present in 32.5% of psoriasis patients and 30% of controls, a non-significant difference.
- Higher age and female gender correlated with MS presence in psoriasis patients.
- MS in psoriasis patients was independent of disease severity (Psoriasis Area and Severity Index, body surface area) and psoriatic arthropathy.
Conclusions:
- No significant correlation was found between psoriasis and metabolic syndrome in the studied South Indian population.
- Age and female gender are identified as potential risk factors for MS in psoriasis patients, irrespective of disease severity.
Related Concept Videos
01:24Overview of Lipid Metabolism
6.9K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
6.9K
01:20Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
324
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
324
01:29Cholesterol: Significance and Regulation
2.0K
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
2.0K
01:24Type II Diabetes II: Pathophysiology
23
PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
23
01:26Type I Diabetes II: Pathophysiology
68
Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular...
68
01:25Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
439
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
439