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Elevated Levels of Coagulation Factor VIII in Patients With Venous Leg Ulcers

Paulo Ricardo Criado1, Afsaneh Alavi2, Robert S Kirsner3

  • 1University of São Paulo, São Paulo, Brazil.

The International Journal of Lower Extremity Wounds
|May 28, 2014
PubMed

Insights

Thrombophilia, including factor VIII deficiency, is more common in young patients with chronic venous insufficiency. Investigating coagulopathy can aid in managing venous leg ulcers and preventing recurrence.

Area of Science:

  • Vascular Medicine
  • Hematology

Background:

  • Chronic venous disease (CVD) affects millions globally, with venous valvular incompetencies and reflux as key contributors.
  • Increased prevalence of thrombophilia is observed in patients with chronic venous insufficiency (CVI).

Purpose of the Study:

  • To highlight the importance of thrombophilia screening in young patients presenting with venous disease.
  • To emphasize the role of factor VIII deficiency in the context of CVI and chronic leg ulcers.

Main Methods:

  • Case series reporting on three patients with chronic leg ulcers and venous insufficiency.
  • Analysis of plasma for high levels of coagulation factor VIII (FVIII:C) activity and other thrombophilic factors.

Main Results:

  • Three patients with chronic leg ulcers demonstrated high FVIII:C activity and associated thrombophilic factors.
  • This suggests a potential link between specific thrombophilic states and venous disease presentation in younger individuals.

Conclusions:

  • Consideration of thrombophilia workup, particularly for factor VIII deficiency, is crucial in young patients with venous disease, recurrent leg ulcers, or livedoid vasculopathy.
  • Further large-scale studies are needed to establish definitive indications for thrombophilia screening in these patient groups.

Keywords:
coagulopathyfactor VIIIvenous leg ulcer

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