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A multivariate approach to saccharide quantitative structure-activity relationships exemplified by two series of
J Jonsson1, L Eriksson, S Hellberg
1Department of Organic Chemistry, Umeå University, Sweden.
Acta Chemica Scandinavica (Copenhagen, Denmark : 1989)
|March 1, 1989
Abstract:
Multivariate saccharide quantitative structure-activity relationships (QSARs) have been developed for two series of 9-hydroxyellipticine glycosides. In order to describe the structural variation of the glycoside moieties, thirteen chromatographic variables were used. Eleven D-glycosides and seven L-glycosides were used in separate QSARs to model 9-hydroxyellipticine glycoside antitumour activity against L 1210 leukemia. The multivariate partial least squares (PLS) method was used to establish the QSARs.