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Related Experiment Videos

Accidental poisoning with dapsone.

S K Dey, A K Maitra

    Indian Journal of Dermatology
    |December 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    Accidental dapsone poisoning in a patient caused cyanosis and tachycardia. Oral ascorbic acid treatment effectively resolved these severe symptoms, leading to patient recovery.

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    Area of Science:

    • Toxicology
    • Pharmacology
    • Emergency Medicine

    Background:

    • Dapsone is a medication with potential for toxicity at high doses.
    • Accidental overdose can lead to severe clinical manifestations requiring prompt intervention.

    Observation:

    • A patient presented with deep cyanosis and tachycardia after ingesting 30 tablets (3000 mg) of dapsone.
    • The clinical presentation indicated significant dapsone-induced methemoglobinemia.

    Findings:

    • Treatment with ascorbic acid (500 mg orally every 6 hours) was initiated.
    • The patient showed a complete recovery from the toxic effects of dapsone.

    Implications:

    • Ascorbic acid is a viable and effective antidote for dapsone poisoning.
  • This case highlights the importance of recognizing and managing dapsone-induced toxicity promptly.