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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

278
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
278
Allergic Reactions02:06

Allergic Reactions

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Overview
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Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

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While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Asthma-I: Introduction01:29

Asthma-I: Introduction

3.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

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Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
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Related Experiment Video

Updated: Apr 29, 2026

Measuring Local Anaphylaxis in Mice
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Anaphylaxis: an update for dental practitioners.

N G Maher1, J de Looze, G R Hoffman

  • 1John Hunter Hospital, Newcastle, New South Wales.

Australian Dental Journal
|May 28, 2014
PubMed
Summary
This summary is machine-generated.

Dentists need better training to recognize and manage anaphylaxis, a life-threatening emergency. Prompt recognition and intramuscular adrenaline administration are crucial for improving patient outcomes in dental settings.

Keywords:
Adrenalineanaphylaxisdentistryemergencyoffice management

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Area of Science:

  • Emergency Medicine
  • Dental Surgery
  • Immunology

Background:

  • Anaphylaxis is a severe, rapid-onset allergic reaction requiring immediate medical intervention.
  • Dentists report insufficient confidence in identifying and managing anaphylactic events.
  • Dental procedures carry a risk of triggering anaphylaxis.

Observation:

  • This review covers anaphylaxis terminology, pathophysiology, and clinical management specific to dental practice.
  • Case studies highlight anaphylaxis occurrences in oral and maxillofacial surgery.
  • Dentists' ability to recognize symptoms and administer intramuscular adrenaline is examined.

Findings:

  • Effective anaphylaxis management in dentistry hinges on prompt recognition and appropriate intervention.
  • Dentists must be proficient in administering intramuscular adrenaline at correct dosages.
  • Understanding the pathophysiology aids in timely and effective treatment.

Implications:

  • Enhanced training for dentists on anaphylaxis recognition and management is essential.
  • Improved preparedness can reduce morbidity and mortality associated with anaphylaxis in dental settings.
  • This review provides a clinical guide for dental professionals facing anaphylactic emergencies.