Microextraction by packed sorbent: an emerging, selective and high-throughput extraction technique in bioanalysis

Area of Science:

• Analytical Chemistry
• Bioanalysis

Background:

• Sample preparation is critical for accurate analysis, but conventional methods are often complex, time-consuming, and solvent-intensive.
• Traditional techniques can negatively impact analytical performance and data quality due to their labor-intensive and error-prone nature.

Purpose of the Study:

• To provide a comprehensive overview of the micro-extraction by packed sorbent (MEPS) technique.
• To highlight the advantages of MEPS over traditional sample preparation methods in bioanalysis.
• To summarize recent applications of MEPS in the field of bioanalysis.

Main Methods:

• Overview of MEPS technique, including its formats (on- and off-line).
• Discussion of sorbent materials, experimental protocols, and factors influencing MEPS performance.
• Comparison of MEPS advantages and limitations against other sample preparation techniques.

Main Results:

• MEPS offers miniaturization, automation, and high-throughput capabilities.
• The technique enables extremely low or no solvent consumption, aligning with green chemistry principles.
• MEPS demonstrates significant advantages in terms of efficiency and reduced complexity for sample preparation.

Conclusions:

• MEPS is a valuable and advantageous technique for sample preparation in bioanalytical applications.
• The method addresses the limitations of conventional techniques by offering a more efficient, automated, and solvent-sparing approach.
• MEPS shows promise for widespread adoption in bioanalysis due to its performance and applicability.