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Updated: Apr 29, 2026
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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
Published on: November 15, 2017
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Recent advances in proteomics: towards the human proteome.
Kui Wang1, Canhua Huang, Edouard Nice
1The State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, 3800, Australia.
Biomedical Chromatography : BMC
|May 28, 2014
Summary
Proteomics is crucial for mapping the human proteome, identifying protein products, and understanding cellular functions. This knowledge will advance personalized medicine and improve health outcomes.
Area of Science:
- Biochemistry
- Molecular Biology
- Genomics
Background:
- The Human Genome Project (2003) provided the genetic blueprint, necessitating further research into protein expression and function.
- Understanding the human proteome is the next frontier in biology, essential for deciphering cellular mechanisms.
- Proteomics is the key scientific discipline enabling these complex investigations.
Purpose of the Study:
- To review foundational discoveries in proteomics.
- To highlight recent technological advancements in the field.
- To outline the Human Proteome Organization's goal of characterizing all human protein products.
Main Methods:
- Review of historical scientific literature and key discoveries in proteomics.
- Analysis of recent technological innovations impacting proteomic research.
- Discussion of the Human Proteome Organization's strategic objectives.
Main Results:
- Proteomics has evolved significantly since the Human Genome Project.
- New technologies are accelerating the identification and characterization of protein products.
- The goal is to identify and characterize protein products from all 20,300 human genes.
Conclusions:
- Unraveling the human proteome will deepen our understanding of cellular biology.
- This research is foundational for advancements in personalized medicine.
- Improved diagnostics, prognostics, and therapeutics are anticipated outcomes.
