Related Experiment Video
Updated: Aug 15, 2026

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
Published on: September 27, 2017
Infantile acropustulosis
1Institute of Dermatology, Bangkok, Thailand.
Insights
Infantile acropustulosis (IA) is a skin condition affecting infants, characterized by itchy bumps on extremities. This report details a case with atopic dermatitis and high IgE levels, noting negative immunofluorescence.
Area of Science:
- Dermatology
- Pediatrics
- Immunology
Background:
- Infantile acropustulosis (IA) is a recognized dermatosis primarily affecting infants.
- It typically presents as recurrent crops of pruritic papules and pustules on the distal extremities.
Observation:
- This case report describes an infant with IA, atopic dermatitis, and elevated serum IgE.
- Immunofluorescent studies of affected skin were negative.
Findings:
- Infantile acropustulosis presents with characteristic clinical and histological features.
- Differential diagnosis for IA is discussed, highlighting its uncommon but not rare occurrence.
Implications:
- Understanding IA's presentation and associations aids in diagnosis and management.
- Further research may elucidate the role of IgE in IA pathogenesis.
Abstract:
Infantile acropustulosis (IA) is a well-recognised syndrome described primarily among black male infants, which may also occur among white and East Asian children. The eruption occurs mainly on the distal areas of the extremities and is characterised by recurrent crops of 1 to 2 mm pruritic papules and pustules in infants from 2 to 10 months of age. We report one patient with infantile acropustulosis and a history of atopic dermatitis and abnormally high IgE serum value. Immunofluorescent studies of involved skin gave negative results. Infantile acropustulosis has been reported by several authors within recent years. The clinical and histological features and differential diagnosis of infantile acropustulosis are discussed. This disease is uncommon but not rare, and persists for about two years.
Related Concept Videos
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Reticular Dermis
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Acne Infection
Rocky Mountain Spotted Fever
Smallpox
Chickenpox

