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Related Experiment Videos

Ketamine for intravenous regional anesthesia.

Z Durrani1, A P Winnie, E K Zsigmond

  • 1Department of Anesthesiology, University of Illinois College of Medicine, Chicago.

Anesthesia and Analgesia
|March 1, 1989
PubMed
Summary

Ketamine intravenous regional anesthesia (IVRA) at 0.5% and 0.3% concentrations provided adequate upper extremity anesthesia in volunteers. However, psychotomimetic side effects limit ketamine

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Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • Intravenous regional anesthesia (IVRA) is a technique for limb anesthesia.
  • Ketamine, an anesthetic agent, has been explored for IVRA.

Purpose of the Study:

  • To evaluate the efficacy and side effects of ketamine for IVRA of the upper extremity.

Main Methods:

  • Volunteers received ketamine IVRA at 0.5%, 0.3%, and 0.2% concentrations.
  • Anesthesia, sympathetic, sensory, and motor blockade were assessed.

Main Results:

  • 0.5% and 0.3% ketamine concentrations produced adequate anesthesia.
  • 0.2% concentration resulted in inadequate anesthesia.
  • 0.3% concentration caused significant psychotomimetic effects post-tourniquet release.

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Conclusions:

  • Ketamine at 0.5% and 0.3% is effective for upper extremity IVRA.
  • Unpleasant psychotomimetic effects limit ketamine's utility in IVRA.
  • Further research is needed to mitigate ketamine's side effects for IVRA.