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Related Concept Videos

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Life tables are versatile across various fields, providing a quantitative basis for analyzing mortality and survival rates. Whether used by demographers, actuaries, epidemiologists, or sociologists, life tables offer valuable insights into the dynamics of life and death, facilitating informed decisions in public health, insurance, conservation, and beyond. Their broad applicability highlights the interconnectedness of demographic data with practical outcomes in everyday life and strategic...
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Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
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Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice
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Osteoporosis: a lifecourse approach.

Nicholas Harvey1, Elaine Dennison, Cyrus Cooper

  • 1Medical Research Council (MRC) Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK; National Institute for Health Research (NIHR) Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|May 28, 2014
PubMed
Summary
This summary is machine-generated.

Osteoporosis risk begins early in life, influenced by growth from conception. Early life interventions may optimize bone health, reducing future fracture risk.

Keywords:
BONE MASSEPIGENETICFRACTUREGROWTHINTRAUTERINELIFECOURSEVITAMIN D

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Area of Science:

  • Bone biology and developmental origins of health and disease (DOHaD).

Background:

  • Osteoporosis risk is accrued across the entire lifespan, starting from early development.
  • Early growth patterns are linked to peak bone mass, aging bone health, and hip fracture risk.

Purpose of the Study:

  • To investigate the relationship between intrauterine and postnatal growth and later bone development.
  • To understand the mechanistic underpinnings, including epigenetic factors, of early growth's impact on bone health.

Main Methods:

  • Analysis of mother-offspring cohorts.
  • Study of biological samples to characterize mechanistic factors.

Main Results:

  • Novel findings reveal connections between early growth patterns and subsequent bone development.
  • Epigenetic processes identified as potential contributors to bone health outcomes.

Conclusions:

  • Global policy acknowledges the role of early growth and nutrition in preventing adult chronic diseases like osteoporosis.
  • Pregnancy interventions are being tested to enhance offspring bone health, aiming for public health strategies to reduce osteoporotic fractures.