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Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models
Published on: January 5, 2024
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Cancer-related coagulopathies
1Department of Medicine and Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands.
Thrombosis Research
|May 28, 2014
Summary
Cancer and thrombosis share known links, including venous thromboembolism and disseminated intravascular coagulation (DIC). This review explores cancer-related coagulation and vascular dysfunction mechanisms, including subclinical activation.
Area of Science:
- Oncology
- Hematology
- Vascular Biology
Background:
- The association between cancer and thrombosis is well-established.
- Cancer patients exhibit diverse coagulation and vascular abnormalities beyond venous thromboembolism.
- These include systemic coagulation activation and microvascular dysfunction.
Purpose of the Study:
- To review the mechanisms of systemic coagulation activation in cancer patients.
- To discuss disseminated intravascular coagulation (DIC) in cancer, noting its typically less acute presentation compared to sepsis or trauma.
- To examine the role of endothelial dysfunction in cancer-related microvascular issues, particularly with chemotherapy or radiotherapy.
Main Methods:
- Literature review focusing on cancer-associated thrombosis and coagulation disorders.
- Analysis of mechanisms underlying systemic coagulation activation.
- Review of endothelial dysfunction in cancer and treatment-related microvascular complications.
Main Results:
- Cancer involves a spectrum of coagulation derangements and vascular disturbances.
- Disseminated intravascular coagulation (DIC) in cancer often presents subclinically or chronically.
- Perturbed endothelium contributes to microvascular dysfunction and microangiopathy in cancer patients undergoing treatment.
Conclusions:
- Cancer-induced hypercoagulability contributes to venous thromboembolism.
- Understanding these mechanisms is crucial for managing cancer-related thrombotic and vascular complications.
- Endothelial dysfunction is a key factor in cancer-related microvascular pathology.
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