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Sustained-release from nanocarriers: a review.

Jayaganesh V Natarajan1, Chandra Nugraha1, Xu Wen Ng1

  • 1Nanyang Technological University, School of Materials Science and Engineering, Blk N4.1, Nanyang Avenue, Singapore 639798.

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Nanocarriers offer drug delivery advantages, but often lack sustained release. This review explores research enabling long-term drug release from nanocarriers for non-cancer nanotherapeutics.

Keywords:
Drug deliveryLocalized drug releaseNanocarriersSustained drug releaseTargeting

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Pharmacology

Background:

  • Nanocarriers have been utilized for drug delivery for over 35 years.
  • Approved nanocarrier products, like Doxil®, primarily focus on cancer chemotherapy.
  • Current nanocarriers generally offer limited sustained drug release, typically lasting only a few days.

Purpose of the Study:

  • To investigate the reasons behind the limited sustained-release capabilities of current nanocarriers.
  • To review successful research in developing sustained-release nanocarrier systems for non-cancer applications.
  • To highlight the advantages and disadvantages of various nanocarrier types for sustained release.

Main Methods:

  • Literature review of existing nanocarrier research.
  • Analysis of nanocarrier properties influencing drug release kinetics.
  • Examination of case studies demonstrating sustained release in non-cancerous contexts.

Main Results:

  • Identified factors limiting sustained drug release from nanocarriers.
  • Presented successful strategies and nanocarrier designs for achieving prolonged drug release.
  • Evaluated the efficacy and limitations of diverse nanocarrier platforms.

Conclusions:

  • Overcoming limitations in sustained release is crucial for expanding nanocarrier applications.
  • Successful sustained-release nanocarriers in non-cancer fields offer significant therapeutic potential.
  • Advancements in nanocarrier design pave the way for novel nanotherapeutics.