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Predictive value of gelsolin for the outcomes of preterm neonates: a pilot study
Mehmet Kose1, Tuba Elmas1, Selma Gokahmetoglu2
1Department of Pediatrics, Division of Pediatric Pulmonology Unit, Erciyes University, Kayseri, Turkey.
Background:
Plasma gelsolin is a circulating actin-binding protein that has a protective role against tissue injuries. Our aim was to compare the baseline levels of gelsolin in premature infants with neonatal outcomes.
Methods:
A total of 32 preterm neonates born at 23-32 weeks of gestation were enrolled in the study.
Results:
Plasma gelsolin levels at 72 h were significantly lower in patients with respiratory distress syndrome, in patients who were administered surfactant therapy and in patients who developed sepsis (P < 0.05). Plasma gelsolin levels at 28 days were significantly lower in patients who developed bronchopulmonary dysplasia and retinopathy of prematurity (P < 0.05).
Conclusions:
Low plasma gelsolin levels in the first postnatal month may be associated with poor outcomes in premature infants.
