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Ma Huang, du complement alimentaire a l'abus.

J Arditti1, J H Bourdon, M Spadari

  • 1Tel : 04 91 74 50 19, Correspondance : Hôpital Salvator. Laboratoire de Toxicologie - Centre antipoison - 249 boulevard de Sainte Marguerite - 13009 Marseille.

Acta Clinica Belgica
|May 28, 2014
PubMed
Summary
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Dietary supplements with Ma Huang (Chinese ephedra) pose serious health risks, including cardiovascular and neurological events, leading to permanent injury and death. Regulatory limits are being considered due to severe adverse reactions.

Area of Science:

  • Pharmacology
  • Toxicology
  • Public Health

Background:

  • Dietary supplements containing Ma Huang (Chinese ephedra) are widely marketed for weight reduction and energy enhancement in the USA.
  • These products often combine Ma Huang with other substances like Guarana, creatine, St. John's Wort, and carnitine.
  • Adverse reactions and acute intoxications linked to these supplements have been documented in medical literature.

Purpose of the Study:

  • To review adverse events associated with Ma Huang-containing dietary supplements.
  • To highlight the potential health hazards and inform the public, medical community, and health authorities.

Main Methods:

  • Review of 140 adverse event reports submitted to the Food and Drug Administration (FDA) between June 1997 and March 1999.
  • Analysis of reported symptoms, severity, and outcomes, including fatalities and permanent impairments.
Keywords:
Ma Huang,abus.complément alimentaire,éphédrine,

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Main Results:

  • 47% of adverse events involved cardiovascular symptoms, and 18% involved neurological symptoms.
  • Severe hypertension, tachycardia, myocardial infarction, stroke, and seizures were frequently reported.
  • Ten deaths and 13 permanent impairments were linked to the use of these supplements.

Conclusions:

  • Ma Huang-containing dietary supplements present significant health risks, including severe cardiovascular and neurological adverse effects.
  • The documented cases of permanent injury and death underscore the need for regulatory oversight and public awareness.
  • Further information is crucial for the general public, medical professionals, and health authorities regarding the potential dangers of these products.