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[Bilateral spontaneous pneumothorax as a setting of Langerhans cell histiocytosis]
Jesús Javier Martínez García1, Mirna Guadalupe Rios Osuna2, Eduardo Altamirano Álvarez2
1Unidad de Terapia Intensiva Pediátrica, Hospital Pediátrico de Sinaloa, Dr. Rigoberto Aguilar Pico.
Abstract:
Pulmonary Langerhans cell histiocytosis is an interstitial lung disease that results from the accumulation of specific histiocytic cells in the lung. Spontaneous pneumothorax is a recognized feature of pulmonary Langerhans cell histiocytosis and results from destruction of lung parenchyma with associated cystic changes. We report on a 2-year-old boy with recurrent bilateral spontaneous pneumothorax; a computed tomography scan showed marked interstitial changes, fibrosis, cystic spaces and bilateral bullae. The diagnosis was confirmed by the histology and the immunohistochemistry examination of the pulmonary biopsy with CD1 and S100 positive antibodies. The child was treated with prednisone and etoposide, and had a good clinical response and favorable changes in the second thoracic CT scan.
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