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Related Concept Videos

Mass Analyzers: Common Types01:19

Mass Analyzers: Common Types

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The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
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The mass analyzer is a crucial component of the mass spectrometer. In the ionization chamber, the vaporized sample is bombarded with a high-energy electron beam to generate a radical cation and further fragment into neutral molecules, radicals, and cations. A series of negatively charged accelerator plates accelerate the cations into the mass analyzer. The mass analyzer separates ions according to their mass-to-charge (m/z) ratios and then directs them to the detector. The common types of mass...
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Mass Spectrometers

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This lesson details the instrumentation of a mass spectrometer—a physical instrument to perform mass spectrometry on analyte molecules and record the characteristic mass spectra. This is achieved via three chief functions:
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Higher molecular weight biomolecules are nonvolatile compounds that may decompose before ionizing or vaporizing during mass analysis with conventional electron impact ionization methods. Accordingly, electrospray ionization (ESI) is the favored method for vaporizing and ionizing biomolecules as it circumvents rapid fragmentation and enables the recording of mass signals for the entire biomolecule.
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Tandem Mass Spectrometry01:21

Tandem Mass Spectrometry

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Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and reduce chemical noise during analyte detection. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called...
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Mass Spectrum: Interpretation

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An unknown compound can be established by identifying the molecular ion peak in the mass spectrum. The molecular ion peak is often weak or absent due to the predominance of fragmentation in high-energy electron beams. In such cases, a soft-energy electron beam can be used to scan the spectrum to enhance the intensity of the molecular ion peak. Additionally, chemical ionization, field ionization, and desorption ionization spectra are used to obtain a relatively intense molecular ion peak.To...
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Novel linear ion trap mass analyzer built with triangular electrodes.

Yu Xiao1, Zhengzhi Ding, Chongsheng Xu

  • 1Department of Chemistry and Laser Chemistry Institute, Fudan University , Shanghai, 200433, China.

Analytical Chemistry
|May 28, 2014
PubMed
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A new triangular-electrode linear ion trap (TeLIT) offers mass analysis and tandem mass spectrometry functions. Its simple design and good performance suggest potential for miniaturization into portable mass spectrometers.

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Area of Science:

  • Analytical Chemistry
  • Mass Spectrometry Instrumentation

Background:

  • Conventional linear ion traps (LITs) utilize precisely shaped hyperbolic electrodes.
  • Simplified LIT designs often compromise performance due to geometric or mechanical tolerances.

Purpose of the Study:

  • To develop and characterize a novel linear ion trap mass analyzer using triangular electrodes (TeLIT).
  • To evaluate the TeLIT's performance for ion trapping, mass analysis, and tandem mass spectrometry.

Main Methods:

  • Construction of the TeLIT using four triangular and two planar electrodes.
  • Simulation of the electric field distribution within the ion trap region.
  • Performance characterization through routine mass analysis and ion manipulation experiments.

Main Results:

  • The TeLIT demonstrated capabilities for ion trapping, mass analysis, and tandem mass spectrometry.
  • Achieved a resolving power greater than 1500 at m/z = 609 Th.
  • Exhibited comparable performance to other LITs in mass-selected isolation, ejection, and collision-induced dissociation.

Conclusions:

  • The TeLIT, with its simpler geometry and larger tolerances, offers high potential mass resolution.
  • Its compact size, simple structure, and analytical performance make it suitable for miniaturization.
  • The TeLIT is a promising platform for developing portable mass spectrometers.