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Influence of hyperhomocysteinemia on left ventricular diastolic function in Chinese patients with hypertension

L Ruhui1, J Jinfa, X Jiahong

  • 1Department of Cardiology, Tongji Hospital, Tongji University, No. 389 Xincun Road, 200065, Shanghai, China.

Herz
|May 28, 2014
PubMed

Insights

High homocysteine levels significantly impair left ventricular diastolic function in Chinese hypertensive patients. This indicates a strong correlation between elevated homocysteine and worsened diastolic function indices.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Biochemistry

Background:

  • Essential hypertension is a prevalent cardiovascular risk factor.
  • Elevated plasma homocysteine (Hcy) is linked to cardiovascular disease.
  • The impact of Hcy on left ventricular (LV) diastolic function in hypertensive patients requires further elucidation.

Purpose of the Study:

  • To investigate the association between plasma homocysteine levels and left ventricular diastolic function.
  • To assess the effect of high homocysteine (Hhcy) on LV diastolic parameters in Chinese patients with essential hypertension.

Main Methods:

  • A cohort of 74 Chinese patients with essential hypertension was studied.
  • Participants were categorized into two groups: high Hcy (Hhcy) and normal Hcy (control).
  • Transthoracic Doppler echocardiography was utilized to evaluate LV diastolic function.

Main Results:

  • Patients with Hhcy exhibited significantly impaired LV diastolic function compared to controls.
  • Key echocardiographic parameters showed significant differences: higher E/e' ratio, lower e'/a' ratio, and longer left atrial (LA) diameter in the Hhcy group.
  • Plasma Hcy levels demonstrated a direct correlation with LV diastolic echocardiographic parameters.

Conclusions:

  • Elevated plasma homocysteine levels significantly deteriorate left ventricular diastolic function in Chinese hypertensive patients.
  • Significant correlations exist between LV diastolic function indices and plasma Hcy levels.
  • Plasma homocysteine is a potential contributing factor to diastolic dysfunction in essential hypertension.
Abstract

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