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Disseminated BCG in an infant with interleukin-12 receptor B1 (IL12RB1) deficiency

Manouri P Senanayake, D S Kumararatne, Rainer Doffinger

    Paediatrics and International Child Health
    |May 28, 2014
    PubMed

    Insights

    Neonatal bacille Calmette-Guérin (BCG) vaccination complications in infants may signal primary immunodeficiency disorders. Early detection and treatment of interleukin-12 receptor beta 1 (IL12RB1) deficiency are crucial for recovery.

    Area of Science:

    • Immunology
    • Pediatrics
    • Infectious Diseases

    Background:

    • Neonatal bacille Calmette-Guérin (BCG) vaccination is standard but can cause disseminated disease in rare cases.
    • Disseminated BCG infection is often linked to underlying primary immunodeficiency disorders, particularly in HIV-negative infants.
    • A familial history of similar severe reactions to BCG vaccination warrants thorough investigation.

    Keywords:
    Interleukin-12 receptor B1 (IL12RB1) deficiencyMendelian susceptibility to mycobacterial disease,Neonatal BCG vaccination,

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