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Overview of Exosomes

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...

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Updated: Apr 29, 2026

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Published on: May 24, 2019

Exosomes as immunotheranostic nanoparticles.

Natasha G¹, Buket Gundogan¹, Aaron Tan²

¹Centre for Nanotechnology and Regenerative Medicine, Division of Surgery and Interventional Science, University College London, London, United Kingdom; UCL Medical School, University College London, London, United Kingdom.

Clinical Therapeutics

|May 28, 2014

Summary

This summary is machine-generated.

Exosomes, small vesicles involved in cell communication, show promise as cancer vaccines and diagnostic tools. Their biocompatibility makes them ideal for drug delivery and overcoming limitations of current diagnostic methods.

Keywords:

Exosomes cancer vaccine immunotherapy nanomedicine nanoparticles theranostics

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Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

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An Innovative Method for Exosome Quantification and Size Measurement

An Innovative Method for Exosome Quantification and Size Measurement

Published on: January 17, 2015

Area of Science:

Cellular Biology
Nanotechnology
Immunology

Background:

Exosomes are nanoscale extracellular vesicles mediating intercellular communication.
They play roles in signal transduction, genetic material transport, and immune response modulation.
Exosomes hold potential as therapeutic agents and diagnostic biomarkers for various diseases.

Purpose of the Study:

To present exosomes as immunologic agents for cancer vaccines.
To explore their therapeutic and diagnostic capabilities.
To highlight their potential in cancer immunotherapy.

Main Methods:

Extensive literature search using PubMed, Web of Knowledge, and Google Scholar.
Compilation of clinical trials involving exosomes from clinicaltrials.gov.
Focus on studies utilizing exosomes as immunotheranostic nanoparticles.

Main Results:

Exosomes serve as effective drug and gene delivery vehicles with excellent biocompatibility.
They offer potential as diagnostic biomarkers, surpassing limitations of invasive methods.
Evidence suggests exosomes can form the basis for future cell-free cancer vaccines.

Conclusions:

Exosomes possess diverse functions with significant clinical potential.
Their dual diagnostic and therapeutic applications are vast.
Exosomes represent a promising frontier in nanomedicine and oncology.