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Updated: Apr 29, 2026
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Author Spotlight: Two-Step Tag-Free Isolation of Mitochondria for Improved Protein Discovery and Quantification
Published on: June 2, 2023
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Mitochondria in monocytes and macrophages-implications for translational and basic research
Saranya Ravi1, Tanecia Mitchell1, Philip Kramer1
1Department of Pathology, UAB Mitochondrial Medicine Laboratory, Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL, USA.
Summary
Mitochondria are key to immune cell function. Understanding monocyte and macrophage bioenergetics in diseases like atherosclerosis and chronic kidney disease (CKD) can reveal new therapeutic targets.
Area of Science:
- Immunology
- Cellular Metabolism
- Systemic Diseases
Background:
- Mitochondria regulate immune responses in monocytes and macrophages.
- Dysfunctional monocytes/macrophages contribute to chronic inflammation in atherosclerosis and chronic kidney disease (CKD).
- Macrophage polarization (M1/M2) involves distinct metabolic reprogramming.
Purpose of the Study:
- To review the mitochondrion's role in monocyte and macrophage function.
- To explore the influence of these cells on atherosclerosis and CKD pathophysiology.
- To propose assessing monocyte bioenergetics for therapeutic insights.
Main Methods:
- Literature review focusing on mitochondrial function in monocytes and macrophages.
- Analysis of cellular metabolism in M1 and M2 macrophage phenotypes.
- Examination of the link between mitochondrial dysfunction and systemic diseases.
Main Results:
- Mitochondria are central to immune cell responses and metabolic reprogramming.
- Altered mitochondrial function in monocytes/macrophages impacts inflammation in atherosclerosis and CKD.
- Distinct bioenergetic profiles correlate with macrophage polarization states.
Conclusions:
- Mitochondrial dysfunction is implicated in the pathogenesis of atherosclerosis and CKD.
- Assessing monocyte bioenergetics can deepen understanding of inflammatory diseases.
- Targeting mitochondrial pathways may offer novel therapeutic strategies for systemic inflammatory disorders.
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