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Acute funisitis is associated with distinct changes in fetal hematologic profile.
Eun Na Kim1, Chong Jai Kim, Jeong Woo Park
1Department of Obstetrics and Gynecology, Seoul National University College of Medicine , Seoul , Republic of Korea .
Summary
Preterm newborns with funisitis show elevated white blood cell counts and reduced red blood cell counts. This indicates significant hematologic changes in neonates experiencing the fetal inflammatory response syndrome.
Area of Science:
- Neonatal Medicine
- Pediatric Hematology
- Obstetrics
Background:
- Acute funisitis is a key indicator of the fetal inflammatory response syndrome.
- Understanding its impact on neonatal hematology is crucial for preterm infants.
Purpose of the Study:
- To investigate the hematologic profiles of preterm newborns diagnosed with funisitis.
- To compare blood cell counts in neonates with and without funisitis.
Main Methods:
- Umbilical cord blood samples from 197 preterm neonates (before 34 weeks gestation) were analyzed.
- Samples were categorized based on the presence or absence of acute funisitis.
- Hematologic parameters including leukocyte, neutrophil, monocyte, and red blood cell counts were compared.
Main Results:
- Funisitis was present in 22.3% of neonates.
- Newborns with funisitis exhibited higher leukocyte, neutrophil, and monocyte counts.
- These infants also showed lower red blood cell counts, hemoglobin, and hematocrit levels.
Conclusions:
- Preterm neonates with funisitis present with distinct hematologic profiles.
- Characterized by elevated white blood cell counts and diminished red blood cell parameters.
- These findings highlight the systemic inflammatory impact of funisitis.
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