Related Experiment Video

Updated: Apr 29, 2026

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

11.8K

Synergistic interactions between anticancer chemotherapeutics and phenolic compounds and anticancer synergy between

Urszula Lewandowska1, Sylwia Gorlach2, Katarzyna Owczarek1

  • 1Department of Biochemistry, Medical University of Lodz, Lodz, Poland.

Postepy Higieny I Medycyny Doswiadczalnej (Online)
|May 28, 2014
PubMed

Insights

Natural polyphenols show promise in cancer prevention and therapy. These plant-derived compounds can work synergistically with synthetic drugs and other phenolics, offering a valuable approach to chemoprevention.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Chemoprevention research is advancing through molecular-level studies of agent mechanisms.
  • Carcinogenesis inhibition has been demonstrated in experimental models by various compounds.
  • Polyphenols from plants are recognized for their diverse biological activities and potential in cancer treatment.

Purpose of the Study:

  • To discuss the efficacy of natural polyphenols in cancer prevention and therapy.
  • To explore the synergistic effects of polyphenols with synthetic anticancer drugs.
  • To evaluate the combined use of different plant-derived phenolic compounds.

Main Methods:

  • Review of existing literature on chemopreventive agents and their mechanisms.
  • Analysis of experimental models demonstrating inhibition of carcinogenesis.
  • Examination of clinical trial data for phenolic compounds and polyphenol-rich extracts.

Main Results:

  • Natural polyphenols exhibit significant potential as chemopreventive agents.
  • Synergy observed between natural polyphenols and synthetic/semisynthetic anticancer drugs.
  • Plant-derived phenolics demonstrate broad-spectrum biological activities relevant to cancer therapy.

Conclusions:

  • Natural polyphenols are effective cancer preventive and therapeutic agents.
  • The synergistic action of polyphenols enhances their anticancer efficacy.
  • Polyphenols represent a valuable alternative or adjunct to conventional cancer treatments.

More Related Videos

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions07:40

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

Published on: May 27, 2021

3.4K
Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro12:00

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro

Published on: July 5, 2017

18.7K

Related Concept Videos

Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
6.2K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.0K
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
157
Combined Effects of Drugs: Antagonism01:30

Combined Effects of Drugs: Antagonism

The combined effects of drugs can result in various interactions, of which an important type is antagonism. Antagonism is a mechanism where one drug inhibits or counteracts the effects of another drug. Antagonism can occur through various means, including receptor binding, allosteric modulation, functional interaction, chemical reactions, and pharmacokinetic processes.
The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...
11.5K
Pharmacokinetics: Drug–Drug Interactions01:25

Pharmacokinetics: Drug–Drug Interactions

Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...
812