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Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
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Association between Ocular Pseudoexfoliation and Sensorineural Hearing Loss.
Nandini Vijaya Singham1, Mimiwati Zahari1, Mohammadreza Peyman1
1Department of Ophthalmology, University of Malaya, Lembah Pantai, 59100 Kuala Lumpur, Malaysia.
Journal of Ophthalmology
|May 28, 2014
Summary
Ocular pseudoexfoliation (PXF) is associated with sensorineural hearing loss (SNHL). This study found PXF patients had significantly higher hearing thresholds, indicating a link beyond the eye.
Area of Science:
- Ophthalmology
- Audiology
- Genetics
Background:
- Ocular pseudoexfoliation (PXF) is a systemic condition.
- PXF is characterized by the deposition of fibrillar extracellular material.
- The systemic effects of PXF are not fully understood.
Purpose of the Study:
- To investigate the association between ocular pseudoexfoliation (PXF) and sensorineural hearing loss (SNHL).
- To compare hearing thresholds in patients with PXF and controls.
Main Methods:
- A case-control study involving 123 patients (68 with PXF, 55 controls).
- Pure-tone audiometry (PTA) was performed at speech-relevant frequencies (250-2000 Hz).
- Patients were categorized into PXF, pseudoexfoliative glaucoma (PXEG), and control groups.
Main Results:
- 60% of patients with hearing loss were in the PXF group.
- PXF patients exhibited significantly higher hearing thresholds compared to controls (P=0.01).
- No significant difference in mean hearing thresholds between PXF, PXEG, and control groups in either ear.
Conclusions:
- An association exists between ocular pseudoexfoliation and sensorineural hearing loss.
- Pseudoexfoliation syndrome can affect organs beyond the eye.
- Further research is needed to elucidate the mechanisms linking PXF and SNHL.
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