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Does long-term use of silver nanoparticles have persistent inhibitory effect on H. pylori based on Mongolian gerbil's
Chao-Hung Kuo1, Chien-Yu Lu2, Yuan-Chieh Yang3
1Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, 100 Tz-You 1st Road, Kaohsiung City 807, Taiwan ; Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung City 807, Taiwan.
Background:
It is urgent to find alternative agents due to increasing failure rate of Helicobacter pylori (H. pylori) eradication. The study surveyed the long-term effect of silver nanoparticles (AgNP) on H. pylori based on Mongolian gerbil's model.
Materials And Methods:
Fifty gerbils were randomly allocated to six groups (A-F). Group (Gr) A: the gerbils were fed with broth; Gr B and D: the gerbils were fed with AgNP/clay complex (0.1% of weight); Gr C and E: the gerbils were fed with AgNP/clay complex(1% of weight); and Gr D, E, and F: the gerbils were inoculated with H. pylori. At the 20th experimental week, the gerbils were sacrificed. Histology was evaluated according to the classification of the Sydney system. P < 0.05 was considered to be statistically significant.
Results:
The AgNP/clay has more obvious inhibitory effect on H. pylori in vitro. There was a trend of higher concentrations of AgNP with stronger inhibitory effect on H. pylori growth (P = 0.071). There were no significant differences of inflammation among groups D, E, and F (P = 0.688).
Conclusion:
AgNP/clay would be a potential and safe agent for inhibiting H. pylori. It should be helpful for eradication of H. pylori infection.
Insights
Silver nanoparticles (AgNP) show potential as a safe agent for inhibiting Helicobacter pylori (H. pylori) infection. This study suggests AgNP/clay could aid in H. pylori eradication, addressing rising treatment failures.
Area of Science:
- Nanotechnology
- Microbiology
- Gastroenterology
Background:
- Increasing Helicobacter pylori (H. pylori) eradication failure rates necessitate novel therapeutic agents.
- Silver nanoparticles (AgNP) are explored as a potential alternative treatment strategy.
Purpose of the Study:
- To investigate the long-term efficacy of silver nanoparticles (AgNP) in an AgNP/clay complex against H. pylori.
- To evaluate the safety and inhibitory effects of AgNP/clay on H. pylori in a Mongolian gerbil model.
Main Methods:
- Fifty Mongolian gerbils were divided into six groups, with varying administrations of AgNP/clay complex and H. pylori inoculation.
- Histological analysis using the Sydney system was performed after 20 weeks to assess inflammation.
- In vitro experiments evaluated the direct inhibitory effect of AgNP/clay on H. pylori growth.
Main Results:
- AgNP/clay demonstrated a notable inhibitory effect on H. pylori in vitro.
- A trend suggested higher AgNP concentrations correlate with stronger H. pylori growth inhibition (P = 0.071).
- No significant differences in H. pylori-induced inflammation were observed among the treatment groups (P = 0.688).
Conclusions:
- AgNP/clay presents as a promising and safe agent for H. pylori inhibition.
- The findings support the potential utility of AgNP/clay in H. pylori eradication strategies.
