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The interaction pattern between a homology model of 40S ribosomal S9 protein of Rhizoctonia solani and
Seema Dharni1, Sanchita2, Abdul Samad3
1Agronomy and Soil Science Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India.
Abstract:
1-Hydroxyphenazine (1-OH-PHZ), a natural product from Pseudomonas aeruginosa strain SD12, was earlier reported to have potent antifungal activity against Rhizoctonia solani. In the present work, the antifungal activity of 1-OH-PHZ on 40S ribosomal S9 protein was validated by molecular docking approach. 1-OH-PHZ showed interaction with two polar contacts with residues, Arg69 and Phe19, which inhibits the synthesis of fungal protein. Our study reveals that 1-OH-PHZ can be a potent inhibitor of 40S ribosomal S9 protein of R. solani that may be a promising approach for the management of fungal diseases.
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