Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Cadmium influence on the rat liver.

M Vojtísek¹, D Hulínská, D Bittnerová

¹Inst. of Hygiene and Epidemiology, CHPNP, Prague, Czechoslovakia.

Acta Morphologica Hungarica

|January 1, 1989

Summary

Cadmium exposure damages rat intestinal and liver tissues, affecting cellular respiration. Metallothionein levels and transport mechanisms vary between organs, influencing toxicity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Serology of Lyme borreliosis and human granulocytic ehrlichiosis in 2005-2010].

Epidemiologie, mikrobiologie, imunologie : casopis Spolecnosti pro epidemiologii a mikrobiologii Ceske lekarske spolecnosti J.E. Purkyne·2011

Same author

The role of electron microscopy in the rapid diagnosis of viral infections--review.

Folia microbiologica·2010

Same author

Identification of Anaplasma phagocytophilum and Borrelia burgdorferi sensu lato in patients with erythema migrans.

Folia microbiologica·2009

Same author

Significance of Borrelia infection in development of dilated cardiomypathy (a pilot study).

Prague medical report·2008

Same author

Molecular and serological evidence of Borrelia burgdorferi sensu lato in wild rodents in the Czech Republic.

Vector borne and zoonotic diseases (Larchmont, N.Y.)·2008

Same author

Phenotypic and genotypic analysis of Borrelia spp. isolated from Ixodes ricinus ticks by using electrophoretic chips and real-time polymerase chain reaction.

Folia microbiologica·2007

Area of Science:

Toxicology
Environmental Health
Cellular Biology

Background:

Cadmium (Cd) is a toxic heavy metal with known adverse effects on various organs.
Understanding cadmium's penetration mechanisms into intestinal and hepatic tissues is crucial for assessing its toxicity.

Purpose of the Study:

To investigate the influence of cadmium on rat intestinal and hepatic tissues.
To elucidate cadmium penetration mechanisms through acute, subchronic, and chronic oral exposure studies.

Main Methods:

In vitro assessment of intestinal scrapings and liver slices respiration using a Clark electrode.
Determination of metallothionein binding to cadmium via column chromatography and spectrophotometry.
Correlation of physiological findings with morphological changes in tissues.

Main Results:

Acute cadmium exposure significantly inhibited intestinal and hepatic tissue respiration.
Metallothionein levels were significantly higher in the liver than in the intestine.
Cadmium penetrates the intestine via passive diffusion and reaches the liver through the bloodstream, causing toxicity.

Conclusions:

Cadmium induces significant physiological and morphological damage in rat intestinal and hepatic tissues.
The liver exhibits a higher capacity for cadmium binding via metallothionein compared to the intestine.
Active transport mechanisms for cadmium appear to be preserved even after chronic exposure.

Related Experiment Videos