Characterisation of up-regulated immunoglobulins in patients with chronic rhinosinusitis

To evaluate the role of immunoglobulins in patients of chronic rhinosinusitis.

Patients were recruited from the Ear, Nose, Throat, Head And Neck Surgery section of Mazandaran University of Medical Sciences, Sari, Iran, from December 2011 to August 2012. Immunoglobulin G, IgG1, IgG2, IgG3, IgG4 were evaluated. Salivary IgA was assessed by direct immunoenzymatic determination. The quantifications of serum IgG, IgG1, IgG2, IgG3, IgG4 and salivary IgA was performed through nephelometric procedure. Serum IgE was measured by enzyme-linked immunoabsorbent assay. SPSS 15 was used for statistical analysis.

Of the 50 patients, 22 (44%) were males and 28 (56%) were females. The overall age ranged from 1 to 67 years with a mean of 28.06 +/- 15.49. There was significant changes in levels of IgG, IgG1, salivary IgA and IgE (p = 0.001). Significant difference was noted for IgG2 (p = 0.03) and in IgG4 (p = 0.01). There was no significant alteration in IgG3 level (p = 0.3).

There was high prevalence of humoral immune alterations both in local and systemic response to chronic inflammation in the patients, which suggests that assessment of immunoglobulin before clinical evaluation and management could be important.