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Iron metabolism: a 40-year overview.

E B Brown1

  • 1Washington University School of Medicine, St. Louis, Missouri.

The American Journal of Medicine
|September 1, 1989
PubMed
Summary

This review summarizes 40 years of human iron metabolism research, highlighting gradual knowledge expansion in hematology. Progress was marked by steady accretion rather than major breakthroughs.

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Area of Science:

  • Hematology
  • Human Physiology
  • Medical Research

Background:

  • Reviews the historical status of hematology, specifically the Hematology Division at Washington University.
  • Establishes a baseline of accepted knowledge in iron metabolism as of 1950.

Purpose of the Study:

  • To summarize the advancements in the study of iron metabolism over the past 40 years.
  • To identify significant additions to the understanding of human iron metabolism.

Main Methods:

  • Retrospective review of hematology and iron metabolism research.
  • Examination of major areas within human iron metabolism.

Main Results:

  • Identifies key additions to knowledge in human iron metabolism.
  • Characterizes scientific progress as a slow accumulation of information.

Conclusions:

  • The field of iron metabolism has advanced through incremental additions to knowledge.
  • No major conceptual breakthroughs have defined the progress in iron metabolism research over the past four decades.

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