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Acute changes in renal function associated with deferoxamine therapy.

G Koren1, Y Bentur, D Strong

  • 1Division of Clinical Pharmacology, Hospital for Sick Children, Toronto, Ontario, Canada.

American Journal of Diseases of Children (1960)
|September 1, 1989
PubMed
Summary
This summary is machine-generated.

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Intravenous deferoxamine can impair kidney function, increasing creatinine levels and decreasing clearance. Maintaining hydration is crucial during deferoxamine therapy to preserve renal hemodynamics.

Area of Science:

  • Nephrology
  • Pharmacology
  • Toxicology

Background:

  • Deferoxamine is a chelating agent used to treat iron overload.
  • Potential renal side effects of deferoxamine require further investigation.

Observation:

  • Patients receiving intravenous deferoxamine showed increased plasma creatinine and decreased creatinine clearance.
  • Two thalassemic patients experienced diuresis during deferoxamine treatment.
  • Canine models demonstrated acute decreases in inulin and para-aminohippuric acid clearances post-deferoxamine administration.

Findings:

  • Deferoxamine significantly reduced glomerular filtration rate and renal blood flow in dogs.
  • Saline diuresis mitigated the decline in glomerular filtration rate but not renal blood flow.
  • Deferoxamine increased fractional excretion of sodium, potassium, chloride, phosphate, and urate.

Related Experiment Videos

  • Ferrioxamine increased sodium and chloride excretion but did not impact renal hemodynamics.

    • Implications:

    • Adequate hydration is recommended to maintain renal hemodynamics during intravenous deferoxamine therapy.
    • Regular monitoring of renal function is advised for patients on deferoxamine.
    • Understanding deferoxamine's renal effects is critical for safe clinical use.