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Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
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Diabetes Mellitus: Type 2 and Gestational01:22

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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Drug Dosing: Obese Patients01:21

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In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
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Regression Toward the Mean01:52

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Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
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Teratogenicity01:07

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Related Experiment Video

Updated: Apr 29, 2026

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators
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Maternal obesity in singleton versus twin gestations: a population-based matched case-control study.

Miha Lucovnik1, Isaac Blickstein, Ivan Verdenik

  • 1Department of Perinatology, Division of Obstetrics and Gynecology, University Medical Centre Ljubljana , Ljubljana , Slovenia and.

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|May 29, 2014
PubMed
Summary

Maternal obesity increases risks for preeclampsia, gestational diabetes, and preterm birth in both twin and singleton pregnancies. However, these adverse outcomes are less common in twin gestations compared to singletons.

Keywords:
Body mass indexgestational diabetes mellituspreeclampsiapregnancypreterm birthtwins

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A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta
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Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Reproductive Health

Background:

  • Pre-pregnancy obesity is a significant risk factor for adverse pregnancy outcomes.
  • Understanding these risks in the context of multiple gestations is crucial for clinical management.

Purpose of the Study:

  • To compare the impact of pre-pregnancy obesity on adverse pregnancy outcomes in twin versus singleton pregnancies.
  • To identify specific risks associated with obesity in dichorionic twin gestations.

Main Methods:

  • Matched cohort study comparing dichorionic twin pregnancies in obese mothers (BMI >30) with non-obese twins and singleton controls.
  • Analysis included rates of preeclampsia, gestational diabetes, cesarean section, and preterm birth.

Main Results:

  • Obese mothers had higher rates of preeclampsia and gestational diabetes in both twin and singleton pregnancies.
  • Cesarean delivery rates were not significantly influenced by obesity in twin pregnancies.
  • Obesity was associated with an increased risk of preterm birth (<34 weeks) in both twin and singleton groups.

Conclusions:

  • Adverse outcomes attributable to maternal obesity appear to be lower in twin pregnancies compared to singleton pregnancies.
  • Maternal obesity consistently increases the risk of preterm birth, irrespective of whether the pregnancy is singleton or twin.